What are the principles that mediate the organization of cells into tissues and organs? How is this organization maintained over the life history of the organism? How do these principles of development and maintenance change over evolutionary time scales? Do new principles of organization come into effect during diseases such as cancer? All the above questions are essentially morphological in character and will conceptually underpin the research carried out in the Bhat laboratory. We will use experimental and theoretical methods in order to understand how form changes or remains unchanged in physiological and pathological contexts.
The behavior and functions of a tissue or organ is the cumulative result of the interactions between its cells and their microenvironment, the molecules of which comprise secretory and matrix proteins, as well as sugars. The information stored by the spatiotemporal patterns of sugars, as decorations of glycoproteins, or as constituents of proteoglycans (PGs) is known as the glycocode. The glycocode is involved in, and changes in a dynamical manner during, development as well as in cancer. We will study the significance of the dynamics of sugars and their interacting proteins in two divergent modes of metastasis, i.e., that of solid tumors (e.g., breast) and peritoneal metastasis (ovarian).
- Singh V, Jha KK, Jyothsna KM, Kumar RV, Raghunathan V, Bhat R. (2019) Iduronate-2-Sulfatase-Regulated Dermatan Sulfate Levels Potentiate the Invasion of Breast Cancer Epithelia through Collagen Matrix. J Clin Med (in press)
- Pally D, Pramanik D, Bhat R (2019) An Interplay Between Reaction-Diffusion and Cell-Matrix Adhesion Regulates Multiscale Invasion in Early Breast Carcinomatosis. Front. Physiol Biophysics 10:790.
- Jha KK, Sarkar P, Biswas R, Bhat R, Raghunathan V. (2019) A Spatiotemporal analysis using second harmonic generation reveals enhancement of Type I Collagen polymerization by dermatan sulfate glycosaminoglycans. Proc. SPIE 11076, Advances in Microscopic Imaging II, 110761G.
- Bhat R, Glimm T, Linde-Medina M, Cui C, Newman SA. (2019) Synchronization of Hes1oscillations coordinate and refine condensation formation and patterning of the avian limb skeleton. Mech Dev. S0925-4773(18)30126-6.
- Gera S, Kumar SS, Swamy SN, Bhagat R, Vadaparty A, Gawari R, Bhat R, Dighe RR (2019) Follicle Stimulating Hormone Is an Autocrine Regulator of the Ovarian Cancer Metastatic Niche Through Notch Signaling. J Endocr Soc. 3(2):340-357.