What are the principles that mediate the organization of cells into tissues and organs? How is this organization maintained over the life history of the organism? How do these principles of development and maintenance change over evolutionary time scales? Do new principles of organization come into effect during diseases such as cancer? All the above questions are essentially morphological in character and will conceptually underpin the research carried out in the Bhat laboratory. We will use experimental and theoretical methods in order to understand how form changes or remains unchanged in physiological and pathological contexts.
The behavior and functions of a tissue or organ is the cumulative result of the interactions between its cells and their microenvironment, the molecules of which comprise secretory and matrix proteins, as well as sugars. The information stored by the spatiotemporal patterns of sugars, as decorations of glycoproteins, or as constituents of proteoglycans (PGs) is known as the glycocode. The glycocode is involved in, and changes in a dynamical manner during, development as well as in cancer. We will study the significance of the dynamics of sugars and their interacting proteins in two divergent modes of metastasis, i.e., that of solid tumors (e.g., breast) and peritoneal metastasis (ovarian).
- Pally D, Goutham S, Bhat R. Extracellular matrix as a driver for intratumoral heterogeneity. Physical Biology. 2022 May. DOI: 10.1088/1478-3975/ac6eb0. PMID: 35545075.
- Pally D, Banerjee M, Hussain S, et al. Galectin-9 signaling drives breast cancer invasion through matrix. bioRxiv; 2022 ACS Chemical Biology. DOI: 10.1101/2021.11.06.467574.
- Pally D, Pramanik D, Hussain S, Verma S, Srinivas A, Kumar R, Arun Everest-Dass, and Ramray Bhat (2021) Heterogeneity in 2,6-Linked Sialic Acids Potentiates Invasion of Breast Cancer Epithelia, ACS Central Science.
- Langthasa J, Sarkar P, Narayanan S, et al. Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids. Life Science Alliance. 2021 Oct;4(10):e202000942. DOI: 10.26508/lsa.202000942.
- Rastogi N, Seth P, Bhat R* and Sen P* Vortex chip incorporating an orthogonal turn for size-based isolation of circulating cells (2021) Anal Chim Acta 1159: 338423.