What are the principles that mediate the organization of cells into tissues and organs? How is this organization maintained over the life history of the organism? How do these principles of development and maintenance change over evolutionary time scales? Do new principles of organization come into effect during diseases such as cancer? All the above questions are essentially morphological in character and will conceptually underpin the research carried out in the Bhat laboratory. We will use experimental and theoretical methods in order to understand how form changes or remains unchanged in physiological and pathological contexts.
The behavior and functions of a tissue or organ is the cumulative result of the interactions between its cells and their microenvironment, the molecules of which comprise secretory and matrix proteins, as well as sugars. The information stored by the spatiotemporal patterns of sugars, as decorations of glycoproteins, or as constituents of proteoglycans (PGs) is known as the glycocode. The glycocode is involved in, and changes in a dynamical manner during, development as well as in cancer. We will study the significance of the dynamics of sugars and their interacting proteins in two divergent modes of metastasis, i.e., that of solid tumors (e.g., breast) and peritoneal metastasis (ovarian).
- Jyothsna K M, Sarkar P, Jha KK, Lal Krishna A S, Raghunathan V, Bhat R (2021) A biphasic response of polymerized Type 1 collagen architectures to dermatan sulfate, Journal of Biomedical Materials Research Part A (accepted) (in press)
- Pally D, Pramanik D, Hussain S, Verma S, Srinivas A, Kumar R, Arun Everest-Dass, and Ramray Bhat (2021) Heterogeneity in 2,6-Linked Sialic Acids Potentiates Invasion of Breast Cancer Epithelia, ACS Central Science.
- Dasgupta D, Pally D, Saini DK, Bhat R and Ghosh A (2020) Nanomotors Sense Local Physicochemical Heterogeneities in Tumor Microenvironments Angew Chem Int Ed Eng.
- Goutham S, Kumari I, Pally D, Singh A, Ghosh S, Akhter Y, Bhat R (2020) Mutually exclusive locales for N-linked glycans and disorder in human glycoproteins. Sci Rep 10, 6040.
- Pal M, Dasgupta D, Somalwar N, Reshma VR, Tiwari M, Pally D, Narayana SM, Katke A, Jayshree RS, Bhat R, Saini DK, Ghosh A (2020) Helical Nanobots as Mechanical Probes of Intra- and Extracellular Environments. J Phys Cond Matt 32: 224001.